AKT1 and cardiovascular disorder: While previous studies suggested anti-proliferative effects of paeonol in cardiovascular diseases [21] and in silico results identified AGE-RAGE and PI3K-Akt pathways as relevant and showed high binding affinity with FGF-1 and TGF-β1 with values over −6 kcal/mol, no previous studies have investigated inhibitory effects of paeonol on local growth factors in BPH.