CASP3 and benign prostatic hyperplasia: While in silico studies revealed CASP3 and BCL-2 among top 10 hub genes and pathway analysis demonstrated apoptosis as relevant, molecular changes in CASP3 and BCL-2 were insignificant, suggesting that paeonol’s alleviating effects against BPH progression are mainly associated with suppression of proliferation rather than enhancement of apoptosis.