TGFB1 and Hepatic fibrosis: In vitro studies by Ye et al. highlighted the possible role of ursodeoxycholic acid (largely used as a therapy in primary biliary cholangitis) in the treatment of liver fibrosis: they discovered that it can exert an effect on the HSCs, reducing collagen production and the autophagic mechanisms induced by TGF-β; the authors underline that similar results were also achieved in mouse models with induced liver fibrosis [200].