HDAC6 and Miyoshi myopathy: Among them, AKOS030273637 (Compound 10), featuring a benzyl 4-[4-(hydroxyamino)-4-oxobutylidene]piperidine-1-carboxylate scaffold, was confirmed to inhibit HDAC6 enzymatic activity, with a significant anti-tumor effect against MM cell lines, including those resistant to standard therapies.