DNMT1 and hepatocellular carcinoma: Overexpression of DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2) has also been frequently observed in HCC and correlates with poor prognosis [23] cause oncogenic transformations, destabilize the genome, change gene expressions, which cause uncontrolled cell proliferation and thus trigger hepatocellular carcinoma [24].