Also, other assays are required to explore the way IA promotes lymphoma cell death in NHL, such as apoptosis (i.e., caspase activity, TUNEL staining, and annexin V/PI flow cytometry) and the effect on the glycolytic pathway (i.e., expression of aldolase A, lactate dehydrogenase, and hexokinase II). The gene discussed is ANXA5; the disease is lymphoma.