APOA4 and alcohol dependence: According to the PPI network, GO, KEGG, and REAC analyses, the DEPs including Fhl1, Il1rap, Ifi44, Timd4, Apoa4, Fabp3, Myh3, Eno 2, and H4c11 may be associated with several processes, including muscle contraction, glycolysis, hemostasis, epigenetic regulation of gene expression, transport of small molecules, neutrophil extracellular trap formation, adrenergic signaling in cardiomyocytes, systemic lupus erythematosus, alcoholism, and platelet activation, signaling, and aggregation (Figure 7, Figure 8, Figure 9, Figure 10 and Figure 11).