Necroptosis (Figure 10A), neutrophil extracellular trap formation, cardiac muscle contraction, and dilated cardiomyopathy (Figure 10B), among others, are some pathways affected by downregulated proteins such as Pgam5, Slc25a4, and H2ax as well as Myl2, Myl3, Atp2a1, and Tpm2. The gene discussed is ATP2A1; the disease is dilated cardiomyopathy.