APOE and atherosclerosis: The combined activation of GIPR and GLP-1R has been observed to attenuate atherosclerotic lesions in transgenic mice expressing apolipoprotein E*3-Leiden (APOE*3-Leiden) and human cholesteryl ester transfer protein (CETP) (APOE*3-Leiden.CETP mice), a humanized dyslipidemic model that develops diet-induced atherosclerosis [26].