(c) The immunological system of eczema focused on T helper type 2 (Th2) cell-derived cytokines, including interleukin (IL)-4 and IL-13, and keratinocyte-derived cytokines, as well as thymic stromal lymphopoietin (TSLP) and IL-33, which contribute to Th2-mediated skin inflammation in AD [99]. Here, IL33 is linked to Alzheimer disease.