PRDM16 and obesity due to melanocortin 4 receptor deficiency: Similar to DHA, Eicosapentaenoic acid (EPA, C20H30O2) in mice also enhances BAT thermogenic properties, increasing PRDM16, PGC1α, and UCP1 expression, and also promotes sWAT browning [82] and muscle NST through SERCA2b and FGF21 upregulation [83], supporting the idea that DHA and EPA could be attractive food-derived bioactive agents to curb obesity.