Cancer cells often rely on aerobic glycolysis, de novo lipid biosynthesis, and glutamine-dependent anaplerosis—processes that are tightly regulated by signalling pathways such as ROS, AMP-activated protein kinase (AMPK), mitogen-activated protein kinases (MAPK), phosphoinositide 3-kinase (PI3K), hypoxia-inducible factor 1-alpha (HIF-1α), and the tumour suppressor protein p53. The gene discussed is HIF1A; the disease is cancer.