It also downregulated the expression of atrogin-1 and MuRF-1 (Figure 3A–C) via inhibiting the elevated nuclear NFκB and FoxO1a in SAMP8 mice (Figure 4), indicating that ETAS® maintains the positive protein balance in aging and mitigates aging-related muscle atrophy. The gene discussed is FBXO32; the disease is muscle atrophy.