Importantly, the impact of periodontitis extends beyond the oral cavity: bacterial by-products, whole microorganisms, and pro-inflammatory mediators such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP) can disseminate into systemic circulation, contributing to low-grade inflammation and vascular injury [8,10,11,12]. This evidence concerns the gene TNF and periodontitis.