The variant was evaluated as a variant of unknown significance in Varsome platform (3 points) (PM1 supporting (1 point): UniProt protein CFAH_HUMAN domain ‘Sushi 7’ has 25 missense/in-frame variants (4 pathogenic variants, 21 uncertain variants and no benign), which qualifies as supporting pathogenic); PM2 supporting (1 point): variant not found in gnomAD genomes, GnomAD exomes homozygous allele count = 0 is less than 2 for AD/AR gene CFH; PP3 Supporting (1 point): MetaRNN = 0.824 is between 0.748 and 0.841 ⇒ supporting pathogenic). This evidence concerns the gene AR and Alzheimer disease.