Among these genes, 7 are linked with Τ−Β+SCID (IL2RG, JAK3, IL7R, PTPRC, CD3D, CD3E and CD247), 9 are involved in Τ−Β−SCID (RAG1, RAG2, DCLRE1C, PRKDC, NHEJ1, LIG4, ADA, AK2 and RAC2) and 14 (ZAP70, TAP1, TAP2, TAPBP, B2M, CIITA, RFXANK, RFX5, RFXAP, DOCK2, CD3G, MALT1, CARD11 and BCL10) are associated with combined immunodeficiency, generally less profound than SCID. The gene discussed is LIG4; the disease is combined immunodeficiency.