Atrial fibrillation and arterial hypertension were more common in HFpEF, while HFrEF patients showed more significant ventricular and atrial remodeling, lower tricuspid annular plane systolic excursion (TAPSE) values, and higher N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels. The gene discussed is NPPB; the disease is Hypertension.