A Web Of Science search was performed with the following structure: (TS = ((“transcatheter aortic valve replacement” OR “tavi” OR “aortic valve stenosis/surgery” OR “aortic valve stenosis/therapy” OR “aortic valve replacement”))) AND TS = (LGALS3 OR GDF-15 OR galectin 3 OR galectin-3). The gene discussed is LGALS3; the disease is aortic valve stenosis.