Overall, in this COVID-19 cohort, male participants exhibited significantly higher baseline levels of fasting glucose, HbA1c, renal markers (urea and creatinine), and cardiovascular biomarkers (troponin) (see Table 2, Table 3, Table 4 and Table 5), reflecting a more pronounced acute physiological burden findings that are consistent with prior reports of heightened immediate COVID-19 severity among men, potentially driven by hormonal differences, immune response variability, or differential ACE2 expression [1,6,25,26]. Here, ACE2 is linked to COVID-19.