SOCS1 and Sepsis: In a murine model of sepsis, miR-155 carried by serum-derived sEVs promotes M1 macrophage polarization by activating the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway and inhibiting Src homology 2 domain-containing inositol-5-phosphatase 1 (SHIP1) and suppressor of cytokine signaling 1 (SOCS1), thereby enhancing macrophage proliferation and amplifying inflammation.