Early diagnosis of arterial hypertension, conducting appropriate chronotropic therapy in hypertension considering the assessment of the hypotensive effect distribution of a given medication throughout the day (smoothness index), and implementing a therapy combining traditional antihypertensive treatment regimens using medications such as calcium blockers, ACE inhibitors/ARBs, and alpha-blockers in combination with new drugs such as SGLT2 inhibitors, may offer greater benefits in terms of better blood pressure control as well as lipid and glycemic management. This evidence concerns the gene SLC5A2 and hypertensive disorder.