ACE and hypertensive disorder: Early diagnosis of arterial hypertension, conducting appropriate chronotropic therapy in hypertension considering the assessment of the hypotensive effect distribution of a given medication throughout the day (smoothness index), and implementing a therapy combining traditional antihypertensive treatment regimens using medications such as calcium blockers, ACE inhibitors/ARBs, and alpha-blockers in combination with new drugs such as SGLT2 inhibitors, may offer greater benefits in terms of better blood pressure control as well as lipid and glycemic management.