On the other hand, in terms of GH secretion, in three cases we observed a “pass” on GST but an inadequate response during ITT (maximal GH 3.14 ng/mL on GST versus 2.42 ng/mL on ITT (female, secondary amenorrhoea, obesity, BMI 38.97 kg/m2, adrenal axis intact), GH 9.61 ng/mL on GST versus 2.48 ng/mL on ITT (male with isolated diabetes insipidus, adrenal axis intact, BMI 24.31 kg/m2), and GH 13.39 ng/mL versus GH 2.45 ng/mL (female, secondary amenorrhoea, obesity, BMI 39.3 kg/m2, adrenal axis intact). The gene discussed is GH1; the disease is obesity due to melanocortin 4 receptor deficiency.