Three patients in the GST group failed to reach cortisol concentrations above 13.6 μg/dL, and in two of these cases higher cortisol concentrations were observed during ITT (13.4 μg/dL versus 15.9 μg/dL (male, history of debulking of pituitary adenoma 70 × 40 × 35 mm accompanied by hypogonadism (LH < 0.1 IU/mL, FSH < 0.3 IU/mL, TSH 1.56 uIU/mL (0.27–4.2), FT4 0.88 ng/L (0.73–1.7), FT3 2.75 pg/mL (2–4.4)), morbid obesity (BMI 47.67 kg/m2), yet with maximal GH 1.21 ng/mL on GST versus GH 0.76 ng/mL on ITT). This evidence concerns the gene PLOD1 and pituitary gland adenoma.