In the multiple linear regression analysis, both obesity (β = 29.68, [95% CI = 1.49, 57.87]; p < 0.05) and glycemic status (β = 48.78, [95% CI = 30.98, 66.58]; p < 0.001) were independently associated with granulin concentrations. The gene discussed is GRN; the disease is obesity due to melanocortin 4 receptor deficiency.