While other studies [71] underscored the connection between HLA-DRB1*04 (a very well-known genetic risk factor for RA, especially severe forms) with extra-articular manifestations (including RV—OR = 2.44, 95% CI: 1.22–4.89), this study emphasized that HLA-C3 significantly increase the risk of vasculitis in patients with HLA-DRB1*04 shared epitope genotype (OR = 2.7, 95% CI: 1.2–6.1), and in patients without the HLA-DRB1*04 shared epitope genotype (OR = 8.3, 95% CI: 2.0–34.2). The gene discussed is HLA-DRB1; the disease is rheumatoid arthritis.