Notably, our results showed higher levels of the cytokines TNFα, IL-6, and IL-17 in CM; even TNF-α was shown to be higher in these than in those with EM; therefore, we cannot assume that chronicity is due to the present inflammation, but rather, we hypothesize that the same inflammation, present and constant, precedes chronicity; however, there are key moments when the attacks are so recurrent that it makes it more complicated for the inflammatory environment to return to a basal state. Here, TNF is linked to erythema multiforme.