However, IL-17 has been poorly evaluated in migraine; for example, in a rat model of migraine induced with NTG, IL-17A was found in the medulla oblongata and associated with neuroinflammation [37], in addition to being elevated in patients with neurodegenerative diseases, directly associating it with neuroinflammation [38], and in others where different treatments were used, it was associated with nano-curcumin and vitamin D3 in patients with episodic migraine, which showed a reduction in IL-17 levels [39,40]. This evidence concerns the gene IL17A and neurodegenerative disease.