A central driver of endothelial damage in atherosclerosis is oxidative stress response from oxidized low-density lipoproteins (oxLDLs) [38] OxLDL interacts specifically with the lectin-like oxidized LDL receptor-1 (LOX-1), thereby triggering several pro-inflammatory signaling cascades, particularly involving activation of the nuclear transcription factor NF-κB [39]. Here, OLR1 is linked to atherosclerosis.