3×Tg-AD mice exhibited a clear phenotypic reduction in the endocannabinoid 2-AG production machinery, as revealed by the decrease in the enzyme for its production Daglb (Figure 9D), and the reduction in the ratio production/degradation, measured as the ratio Dagla/Mgll (Figure 9G), and Daglb/Mgll (Figure 9H). The gene discussed is DAGLA; the disease is Alzheimer disease.