While age is the strongest known risk factor for AD, other contributing factors include insulin resistance, neuroinflammation, dysregulation of glutamatergic and cholinergic neurotransmission, associated with the accumulation of pathological protein aggregates such as amyloid beta (Aβ) plaques and hyperphosphorylated tau neurofibrillary tangles (NFTs) in brain tissues [2,3,4,5,6]. Here, MAPT is linked to Alzheimer disease.