In 3×Tg-AD mice, treatment with DCI tends to reduce the inhibitory phosphorylation of Irs-1 at Serine 307, without affecting PI3K/AKT kinases activation and reducing notably the increased phosphorylation of GSK-3β at serine 9 (Figure 5A,C,E,G). This evidence concerns the gene IRS1 and Alzheimer disease.