3×Tg-AD mice exhibited a marked increase of the mRNA expression of AMPA receptor subunit Gria1 (Figure 7A) and NMDA subunit 2a (Grin2a, Figure 7D) and a decrease in NMDA subunit 1 (Grin1, Figure 7C), NMDA subunit 2b (Grin2b, Figure 7E) and metabotropic type 5 (Grm5, Figure 7F). This evidence concerns the gene GRIN1 and Alzheimer disease.