In comparison to the HCD group, the expression levels of FXR and short heterodimer partner (SHP) in the liver were markedly elevated in the HCD + BPL-4 group (p < 0.05), but the expression of FXR and its downstream genes, FGF15 and intestinal bile acid binding protein (IBABP), in the ileum was dramatically reduced (p < 0.05). Here, NR0B2 is linked to heavy chain disease.