For human extrapolation, clinical associations link low levels of lysine, methionine, and threonine to metabolic imbalances and immune dysfunction, suggesting potential relevance to AMD progression in aging populations with subclinical deficiencies [31]; additionally, methionine metabolism’s influence on glioma angiogenesis via CXCL8 under restriction implies broader therapeutic implications for vascular diseases, including dietary interventions to modulate these EAAs in humans [32]. Here, CXCL8 is linked to central nervous system cancer.