According to the research results, it was shown that the addition of APS-H could inhibit the levels of TNF-α, IL-1β, and IL-6 in serum and their mRNA expression levels in colon tissue, as well as enhancing the secretion of anti-inflammatory cytokines such as IL-22 and IL-10 in the serum and colon tissue of mice with colitis caused by DSS. The gene discussed is IL1B; the disease is colitis.