SOD1 and obesity due to melanocortin 4 receptor deficiency: Experimental studies confirm the efficacy of the restrictive KD in reducing oxidative stress, as demonstrated in a four-week study on young rats with diet-induced obesity, where the KD reduced oxidative stress through an increase in the activity of the antioxidant enzyme superoxide dismutase (SOD) and a decrease in malondialdehyde (MDA-a marker of lipid peroxidation) [59].