PANK1 and Friedreich ataxia: In contrast, pantothenate kinase-associated neurodegeneration (PKAN), and Friedreich’s Ataxia (FRDA) involve neuronal dysregulation at cellular or mitochondrial level classified as neurodegeneration with brain iron accumulation (NBIA) or mitochondrial Fe-S cluster disorders respectively [28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54].