PANK2 and neurodegenerative disease: Pantothenate Kinase-Associated Neurodegeneration: PKAN is an early-onset autosomal-recessive monogenic disorder resulting from mutations in the pantothenate kinase 2 (PANK2) gene, which encodes pantothenate kinase 2, an enzyme that catalyzes the first step in coenzyme A (CoA) biosynthesis by phosphorylating pantothenic acid (Vitamin B5) to form 4’-phosphopantothenate [39,40].