FOS and obesity due to melanocortin 4 receptor deficiency: 60 children and adolescents overweight or with obesity aged 8–18 years were randomly allocated in two group: (i) patients receiving a synbiotic supplement-comprising Lactobacillus coagulans SC-208 and Lactobacillus indicus HU36 (each at 6 × 109 CFU) with FOS; (ii) patients receiving placebo for 8 weeks.