A recent meta-analysis by Li et al. evaluated the effects of probiotics on various metabolic markers in children with obesity, including BMI, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), adiponectin, leptin, and TNF-α [126]. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.