IL6 and osteogenesis imperfecta: Children who received prebiotic supplementation with OI experienced a 3.1% reduction in body weight z-score, a 2.4% decrease in total BFP, and a 3.8% decline in trunk fat.The OI group showed a 19% reduction in serum triglycerides and a 15% decrease in IL-6, whereas IL-6 increased by 25% in the placebo group.Microbiota analysis revealed a selective expansion of Bifidobacterium spp. and a reduction of Bacteroides vulgatus in the prebiotic group.