Interestingly, in a series of previous genetic studies in the same population (Europeans of Central Russia), we found cogent acknowledgement of the crucial role of obesity/overweight as a modifier of genetic variants associations with sex hormone/SHBG-related pathologies such as breast cancer [93,94,95], osteoarthritis [96], and preeclampsia [97]. The gene discussed is SHBG; the disease is osteoarthritis.