The results of our work demonstrated, for the first time, the essential role of obesity/overweight as a meaningful modifier of associations between SHBGlevel-tied polymorphisms and UM: rs17496332 (A/G) PRMT6 was UM-correlated in BMI < 25 group and rs3779195 (T/A) BAIAP2L1 was UM-associated in BMI ≥ 25 cohort. The gene discussed is PRMT6; the disease is obesity due to melanocortin 4 receptor deficiency.