Interestingly, in a series of previous genetic studies in the same population (Europeans of Central Russia), we found cogent acknowledgement of the crucial role of obesity/overweight as a modifier of genetic variants associations with sex hormone/SHBG-related pathologies such as breast cancer [93,94,95], osteoarthritis [96], and preeclampsia [97]. This evidence concerns the gene SHBG and obesity due to melanocortin 4 receptor deficiency.