Although the genetic aspects of NPSLE are only recently being explored, we found one study in pediatric patients with SLE reporting three SNPs in genes regulating immune responses, namely, FCGR3A, IL-17RA, and IL-23R, which significantly increased the risk for pNPSLE development (ORs ranging 4.50–7.83, p < 0.05) [42]. This evidence concerns the gene IL23R and systemic lupus erythematosus.