Despite being less specific for NP involvement, lupus-specific autoantibodies, including anti-RibP, anti-PL, and anti-dsDNA, as well as other common autoimmune disease markers, like ANA and anti-ENA antibodies, were among the most studied biomarkers in pSLE in the 29 analyzed studies, investigated for their potential association with NPSLE. The gene discussed is BTG3; the disease is autoimmune disease.