Although ESR is a nonspecific marker of inflammation, and generally considered less sensitive than CRP, we found a higher AUC for elevated ESR than for CRP or fibrinogen in patients with COVID-19 and AP (0.777 vs. 0.702 and 0.675, respectively), indicating that ESR can be used as a reliable marker to assess the severity of the inflammatory process in patients with COVID-19 and AP. This evidence concerns the gene CRP and COVID-19.