Pathophysiological interrelations between hypertension and DMT2 are based on insulin resistance, disturbances in the renin-angiotensin-aldosterone (RAAS) and sympathetic nervous system functions, mitochondrial impairment leading to oxidative stress, proinflammatory state, dysregulation of glucagon-like peptide signaling, and sodium-glucose cotransporter 2 activity [32]. This evidence concerns the gene SLC5A2 and hypertensive disorder.