Pathophysiological interrelations between hypertension and DMT2 are based on insulin resistance, disturbances in the renin-angiotensin-aldosterone (RAAS) and sympathetic nervous system functions, mitochondrial impairment leading to oxidative stress, proinflammatory state, dysregulation of glucagon-like peptide signaling, and sodium-glucose cotransporter 2 activity [32]. The gene discussed is SLC5A2; the disease is Hypertension.