In eight out of ten RCTs, the functional outcomes, sICH frequency and mortality after IVT with TNK were comparable to IVT with ALT, even in the presence of diabetes and/or hyperglycemia, in patients aged ≥80 years, in posterior circulation vessel occlusion, in carotid tandem lesion, and in minor AIS [14,15,16,17,19]. The gene discussed is GPT; the disease is Hyperglycemia.