KIAA0825 and polydactyly: In the present study, we investigated four consanguineous Pakistani families segregating nonsyndromic PAP and identified KIAA0825 variants which have not previously been reported to be involved in polydactyly: nonsense variant p.(Trp773*) in two families, missense variant p.(Val324Phe) in one family, and a four amino acids deletion p.(Gln915-Val918del) in an additional family.