Further whole-blood biochemical analysis showed that the upregulation of CHDL, TAG, HDL-C, and LDL-C caused by the high-fat, high-sugar diet did not change significantly after adding PA, but the level of LP(a) was significantly improved, which indicates that PA may improve HFD-induced obesity by adjusting the level of LP(a) (Figure 1F). Here, CHD1L is linked to obesity due to melanocortin 4 receptor deficiency.