Biochemical analyses revealed that the HFD significantly elevated serum levels of CHDL, TAG, HDL-C, LDL-C, and LP(a), suggesting an increased risk of cardiovascular diseases; however, when PA was added to the HFD, while there was no impact on the serum concentrations of CHDL, TAG, and LDL-C, HDL-C levels significantly increased and LP(a) levels decreased. Here, CHD1L is linked to cardiovascular disorder.