In obese PCOS, this axis is disrupted by interconnected feedback loops: IR exacerbates HA by overstimulating theca cells, HA aggravates IR through interactions with adipocyte androgen receptors, and both contribute to chronic inflammation mediated by NF-κB, which inhibits glucocorticoid steroidogenesis. The gene discussed is NFKB1; the disease is polycystic ovary syndrome.