Circulating extracellular vesicle microRNA panels (e.g., miR-122, miR-27b, miR-21, miR-103, miR-222, miR-451) and protein signatures (e.g., phosphorylated AKT, SOCS3, adiponectin receptor fragments) can enhance the early identification of metabolic–reproductive dysregulation and the classification of insulin resistance-dominant phenotypes. Here, AKT1 is linked to Insulin resistance.