In PCOS, adipose tissue-derived extracellular vesicles often exacerbate ovarian inflammation by transmitting pro-inflammatory microRNAs (e.g., miR-155, which targets SHIP1 and promotes NF-κB activation); hence, counteracting this signal using modified extracellular vesicles is a viable method [188]. This evidence concerns the gene NFKB1 and polycystic ovary syndrome.