NLRP3 and polycystic ovary syndrome: Monocytes and macrophages exposed to PCOS-derived extracellular vesicles enriched with HMGB1, S100 proteins, and miR-155 undergo NLRP3 inflammasome priming and activation, mediated by mitochondrial reactive oxygen species and potassium efflux through P2X7 receptor channels [141].