Carriers of pathogenic or likely pathogenic (P/LP) variants in MYH7 generally present with an earlier onset of hypertrophic cardiomyopathy, more pronounced left ventricular hypertrophy, and an increased incidence of adverse outcomes, including ventricular arrhythmias and sudden cardiac death, particularly in individuals with a family history of early cardiac events. The gene discussed is MYH7; the disease is hypertrophic cardiomyopathy.