Recurrent gene fusions and chromosomal rearrangements involving MYC, BCL2, and BCL6 are hallmark genetic events in DLBCL and are defining features of specific DLBCL subtypes and high-grade B-cell lymphomas (HGBCL), as per the World Health Organization (WHO) 2016 and 2022 classifications [2,3]. The gene discussed is BCL6; the disease is B-cell non-Hodgkin lymphoma.