Of the 313 patients with cardiomyopathies and available NGS test results, 222 unrelated patients with an HCM phenotype were selected, and the following were excluded from analysis: four individuals with more than one P/LP variant, two with P/LP variants in the PRKAG2 gene, and two individuals with variants in genes showing limited evidence of association with HCM (MYH6, ANK2) (Figure 1). The gene discussed is PRKAG2; the disease is cardiomyopathy.