Monogenic IBD presents other common alterations in the following genes: XIAP (X-linked inhibitor of apoptosis) and FOXP3 (forkhead box P3) [X-linked inheritance], FERMT1 (FERM domain containing kindlin 1), CYBB (cytochrome b-245 beta chain), COL7A (collagen type VII alpha 1 chain) [autosomal recessive inheritance] and GUCY2C (guanylate cyclase 2C) [autosomal dominant inheritance]. This evidence concerns the gene GUCY2C and inflammatory bowel disease.