To explore the expression profile of the JCHAIN in cancer, we analysed JCHAIN gene expression data in 33 cancers from the TCGA database, the JCHAIN was shown to be lowly expressed in BRCA, CHOL, Colon Adenocarcinoma (COAD), Head and Neck Squamous Cell Carcinoma (HNSC), Kidney Chromophobe (KICH), Kidney Renal Papillary Cell Carcinoma (KIRP), Liver Hepatocellular Carcinoma (LIHC), Lung Squamous Cell Carcinoma (LUSC), Rectum Adenocarcinoma (READ), Stomach Adenocarcinoma (STAD), and Thyroid Carcinoma (THCA), but highly expressed in Kidney Renal Clear Cell Carcinoma (KIRC) (Figure 1A,C). This evidence concerns the gene JCHAIN and head and neck squamous cell carcinoma.