YTHDF2 and breast carcinoma: For example, in breast cancer, ALYREF promotes breast cancer development as well as affects cell stemness by influencing transcriptional regulation and mitochondrial energy metabolism [33,34], In another study, YTHDF2 reverses RNA demethylase-induced alterations in cellular phenotype by increasing mRNA stability and promotes cellular proliferation, invasion, and tumorigenic properties in vitro [35].