JCHAIN and neoplasm: In addition, the JCHAIN was found to be negatively associated with aneuploidy, homologous recombination defects (HRDs), mutation rate, and tumour neoantigens (SNV neoantigens) in most cancers, as well as the 30 homologous recombination repair (HRR) signature genes, This shows that DNA damage affects the physiological function of JCHAIN.