In regard to heritable connective disorders, several single reports of Marfan syndrome (MFS) with CDH have been described in the literature [10,11], and CDH is reported in 34% of the patients with arterial tortuosity syndrome [15] and in several reports of LTBP4-cutis laxa [16]. The gene discussed is LTBP4; the disease is congenital diaphragmatic hernia.