In contrast, AD-A LCLs exhibited increased expression of genes associated with intracellular signaling (CAB39), autoimmune processes (IFIT3), and mTOR pathway regulation (DEPTOR), as well as genes involved in transcriptional control (TCEAL8, CHD3, DDX21) and lipid metabolism (LYPLA1). The gene discussed is CHD3; the disease is Alzheimer disease.