This requires glucose uptake and energy sources for normal cellular response to stress and tumor growth, syndrome development, vascular changes, and megalocephaly (e.g., PIK3R1; PIK3CA; PIK3CG; PIK3CD; PIK3CB; PIK3R3; PIK3R2; PIK3R5; PIK3R6). Here, PIK3R2 is linked to neoplasm.