PTEN interacts with TP53 (tumor protein p53), a cellular tumor antigen, and other genes with their encoded proteins, such as MAGI2, AKT1, and PIK3R1, along with other members of the PIK3 gene family which are involved with protein kinase signaling and binding, with phosphatase activity impacting the cell-to-cell junction and myelin sheaths, as described in Table 1. The gene discussed is PTEN; the disease is neoplasm.