Key angiogenic drivers in the diabetic retina include vascular endothelial growth factor (VEGF), insulin/insulin-like growth factors (IGF), and hypoxia-inducible factor-1 alpha (HIF-1α), which are upregulated in response to hyperglycemia and retinal ischemia [59,60,61,62,63]. The gene discussed is HIF1A; the disease is Hyperglycemia.