Furthermore, McArthur K et al. using retinal tissue from streptozotocin-induced diabetic rats and glucose-exposed endothelial cells from Human Umbilical Vein in their experimental study, showed that hyperglycemia in diabetes induces downregulation of miR-200b in rat diabetic retinas, which causes VEGF mRNA upregulation [82]. This evidence concerns the gene VEGFA and Hyperglycemia.