The integration at the pathway level revealed regulatory differences across the entire system (Figure 4B), mainly dominated by the energy-nutrient axis (FoxO signaling pathway, PI3K-Akt signaling pathway, and oxidative phosphorylation), developmental plasticity (Wnt signaling pathway and lysine degradation), pathogen interactions (epithelial cell signaling in Helicobacter pylori infection), and oncogenic characteristics (non-small cell lung cancer). The gene discussed is AKT1; the disease is non-small cell lung carcinoma.