MDM4 and neoplasm: Furthermore, MDM4, KIF14, DEK, E2F3, and CDH11 are consistently identified candidate oncogenes and tumor suppressor (CDH11) genes in retinoblastoma that are associated with recurrent chromosomal gains at 1q, 6p, and 13q and linked to tumor progression, genomic instability, and therapeutic resistance [93,94,95,96].