KEGG pathway analysis (Figure 7C) revealed significant enrichment in inflammatory and infection-related pathways such as nucleotide-binding oligomerization domain -like receptor (NLR) signaling, Tumor Necrosis Factor (TNF) signaling, Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) signaling and Rheumatoid artritis, reinforcing the role of PANoptosis in chronic inflammatory disorders. This evidence concerns the gene TNF and infection.